AZ HB2470

Requires AHCCCS (Arizona's Medicaid program) and its contractors to provide coverage of rapid whole genome sequencing as a separately payable service for members under one year of age with complex or acute illness of unknown etiology in intensive care units or high acuity pediatric care units.

Establishes evidence-based medical necessity criteria including symptoms requiring multiple genetic tests, provider determination that molecular diagnosis is necessary for clinical decision-making, and specific conditions such as congenital anomalies, abnormal laboratory results, refractory seizures, and cardiac abnormalities.

Requires genetic data from covered rapid whole genome sequencing to be used primarily for diagnosing and treating the patient and to comply with HIPAA and HITECH Act privacy standards.

Defines "rapid whole genome sequencing" as investigation of the entire human genome returning preliminary positive results within five days and final results within fourteen days, and includes patient-only sequencing or duo/trio sequencing with biological parents.

Directs the AHCCCS director to submit any necessary waiver applications or state plan amendments to CMS for approval and authorizes adoption of rules needed to implement the coverage requirement.