MN HF3330

Defines rapid whole genome sequencing (rWGS) as investigation of the entire human genome with results returned within 14 days, including patient-only or duo/trio sequencing with biological parents.

Requires health plans covering Minnesota residents to cover rWGS testing for enrollees age 21 or younger with complex or acute illness of unknown etiology who are receiving inpatient hospital services in intensive care, neonatal, or high acuity pediatric care units.

Establishes medical necessity criteria for coverage including symptoms suggesting broad differential diagnosis, timely molecular diagnosis needed for clinical decision-making, and presence of specified conditions such as congenital anomalies, refractory seizures, abnormal cardiac testing, or family genetic history.

Requires separate reimbursement for rWGS services in addition to capitated or bundled payment arrangements unless carrier and provider negotiate increased payment rates that include these services.

Mandates genetic data be used primarily for diagnosis and treatment, protected as health information under HIPAA and Minnesota Health Records Act, effective January 1, 2025.

Extends coverage to medical assistance (Medicaid) recipients under the same requirements, effective January 1, 2025, or upon federal approval, whichever is later.