OK SB1642

Amends Oklahoma's opioid prescription regulations (63 O.S. 2021, Section 2-309I) to allow practitioners to issue initial and subsequent seven-day acute pain opioid prescriptions in divided quantities, which count as a single prescription for regulatory purposes

Maintains the seven-day supply limit for initial acute pain opioid prescriptions and requires all acute pain opioid prescriptions to be for the lowest effective dose of an immediate-release drug

Permits simultaneous issuance of an initial and subsequent seven-day prescription (up to 14 days total) only for major surgical procedures or patients with "confined to home" status, with specific "do not fill until" date requirements

Retains existing exemptions from prescription limits for patients with sickle cell disease, cancer treatment, hospice care, palliative care, long-term care residents, and those receiving substance abuse treatment

Effective date: November 1, 2026